It is now well known that low back pain (LBP) is the leading cause of disability worldwide and that chiropractors can play a pivotal role in the management of this condition. However, the chiropractic profession can achieve wider acceptance and improved cultural authority, particularly within integrated health care delivery systems, by embracing and integrating current scientific research into our approach to evidence-based health care. It is in this context that this Clinical Practice Guideline (CPG) was developed. The aim of this systematic review was to update and combine three previously published clinical guidelines, while answering this question: “What is the effectiveness of chiropractic care, including spinal manipulation (SMT), for nonspecific low back pain?”